Home < Aphrodisiacs Research

An aphrodisiac is an agent which is used in the belief that it increases sexual desire.
The name comes from Aphrodite, the Greek goddess of sensuality.
Throughout history, many foods, drinks, and behaviors have had a reputation for making sex more attainable and/or pleasurable.
However, from a historical and scientific standpoint, the alleged results may have been mainly due to mere belief by their users that they would be effective (i.e., the placebo effect).
In particular, medical science has not substantiated claims that any particular food increases sexual desire or performance.

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Aphrodisiacs Research
Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac
A new analogue of sildenafil was detected in a herbal aphrodisiac. The structure of the compound was established using LC–MS, UV and IR spectroscopy, MS–MS, and NMR. The compound, named thio-homosildenafil is a synthetic N-ethylpiperazine analogue of sildenafil in which also the CO moiety has been converted into a CS group. This is the first time a sildenafil analogue modified at the chromophore was identified as an adulterant of a herbal aphrodisiac. Preliminary pharmacological analysis confirmed the erectogenic potency of thio-homosildenafil.
Keywords: Dietary supplements; Sildenafil analogue; Thio-homosildenafil; Liquid chromatography–mass spectrometry (LC–MS); Nuclear magnetic resonance (NMR)

Application of LC–ESI–MS–MS for detection of synthetic adulterants in herbal remedies
Adulteration of allegedly “natural herbal medicines” with undeclared synthetic drugs is a common and dangerous phenomenon of alternative medicine.
The purpose of the study was to develop a procedure for detection of most common synthetic adulterants in herbal remedies, using high-pressure liquid chromatography-electrospray tandem mass spectrometry (LC–ESI–MS–MS). Eighty drugs belonging to various pharmacological classes were included in the study. For most drugs two transitions were monitored, using protonated or deprotonated molecules as precursor ions. The drugs were isolated from herbal remedies using simple methanol extraction. Chromatographic separation was done in gradient of acetonitrile—10 mM ammonium formate buffer (pH 3.0). Drugs tested were grouped in suites, comprising analgesic drugs, antibiotics, antidiabetic drugs, antiepileptic drugs, aphrodisiacs, hormones and anabolic drugs, psychotropic drugs, and weight reducing compounds. These suites were used according to the declared benefits of examined preparations. Limits of detection ranged from 5 pg to 1 ng per injected sample. Drug-free herbal remedy spiked with eight various pharmaceuticals occurring in adulterated herbal preparations was used for internal proficiency testing. The recoveries of spiked drugs ranged from 63 to 100%. The procedure was applied in everyday casework. Several undeclared drugs were identified in “herbal” remedies, like e.g. sildenafil, tadalafil, testosterone, or glibenclamide. Pharmacological properties of detected drugs always corresponded with the claims of the “natural” remedies. The method presents a valuable extension of standard GC–MS screening used for this purpose.
Keywords: Herbal aphrodisiacs remedies; Synthetic adulterants; LC–MS–MS

Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac
A new analogue of sildenafil was detected in a herbal aphrodisiac. The structure of the compound was established using LC–MS, UV and IR spectroscopy, MS–MS, and NMR. The compound, named thio-homosildenafil is a synthetic N-ethylpiperazine analogue of sildenafil in which also the CO moiety has been converted into a CS group. This is the first time a sildenafil analogue modified at the chromophore was identified as an adulterant of a herbal aphrodisiac. Preliminary pharmacological analysis confirmed the erectogenic potency of thio-homosildenafil.
Keywords: Dietary supplements; Sildenafil analogue; Thio-homosildenafil; Liquid chromatography–mass spectrometry (LC–MS); Nuclear magnetic resonance (NMR), herbal aphrodisiac

Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats
Tribulus terrestris (TT) has long been used in the traditional Chinese and Indian systems of medicine for the treatment of various ailments and is popularly claimed to improve sexual functions in man. Sexual behaviour and intracavernous pressure (ICP) were studied in both normal and castrated rats to further understand the role of TT containing protodioscin (PTN) as an aphrodisiac. Adult Sprague-Dawley rats were divided into five groups of 8 each that included distilled water treated (normal and castrated), testosterone treated (normal and castrated, 10 mg/kg body weight, subcutaneously, bi-weekly) and TT treated (castrated, 5 mg/kg body weight, orally once daily). Decreases in body weight, prostate weight and ICP were observed among the castrated groups of rats compared to the intact group. There was an overall reduction in the sexual behaviour parameters in the castrated groups of rats as reflected by decrease in mount and intromission frequencies (MF and IF) and increase in mount, intromission, ejaculation latencies (ML, IL, EL) as well as post-ejaculatory interval (PEI). Compared to the castrated control, treatment of castrated rats (with either testosterone or TT extract) showed increase in prostate weight and ICP that were statistically significant. There was also a mild to moderate improvement of the sexual behaviour parameters as evidenced by increase in MF and IF; decrease in ML, IL and PEI. These results were statistically significant. It is concluded that TT extract appears to possess aphrodisiac activity probably due to androgen increasing property of TT (observed in our earlier study on primates).
Author Keywords: Tribulus terrestris; Protodioscin; Castration; Sexual behaviour; Intracavernous pressure; Androgens; Aphrodisiac

Aphrodisiac property of Trichopus zeylanicus extract in male mice
Administration of Trichopus zeylanicus leaf (ethanol extract) to male mice stimulated their sexual behaviour as evidenced by an increase in number of mounts and mating performance. This activity of the ethanol extract was concentration dependent and destroyed by heat treatment at 100°C for 15 min. Although oral administration of a single dose (200 mg/kg) was effective, daily administration of the extract for 6 days was found to be more effective. The pups fathered by the drug treated mice were found to be normal with reference to foetal growth, litter size and sex ratio. The water as well as n-hexane extracts of the plant leaf were inactive. The present study reveals for the first time the aphrodisiac activity of Trichopus zeylanicus, an endemic herb of India.
Author Keywords: Trichopus zeylanicus; Aphrodisiac drug; Mating; Sexual stimulation; MiceIndex Terms: aphrodisiac agent; plant extract

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