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Eurycoma is a small genus of three or four species of flowering plants in the family Simaroubaceae, native to tropical southeastern Asia. They are small evergreen trees with spirally arranged pinnate leaves. The flowers are small, produced in large panicles.

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Eurycoma Research
Correlation studies between electronic nose response and headspace volatiles of Eurycoma longifolia extracts
Most herbs have their own characteristic smell due to the presence of volatile compounds. Traditionally, volatiles are analyzed by using sophisticated and expensive gas chromatography (GC) in tandem with a selective mass spectrometric (MS) detector. An alternative approach is described based on the use of an electronic nose. The approach is much simpler than the traditional GC–MS counterparts, but providing key information of the samples analyzed. Using lipids and gas chromatography stationary phase materials with different polarities as sensing membranes, a quartz crystal microbalance smell sensor array has been developed for the analysis of traditional medicinal plants. The headspace vapors of different types of Tongkat Ali (Eurycoma longifolia) extracts were analyzed by the smell sensor and GC–MS. Correlation between the sensor response and the identified compounds were studied using principal component analysis. Some of the identified compounds exhibited good correlation with the quartz crystal microbalance (QCM) sensor array data.
Keywords: Electronic nose; Lipids; Medicinal plants; Eurycoma longifolia

Biphenylneolignans from wood of Eurycoma longifolia
Two novel isomeric 2,2′-dimethoxy-4-(3-hydroxy-1-propenyl)-4′-(1,2,3-trihydroxypropyl) diphenyl ethers, and two novel biphenyls, 2-hydroxy-3,2′,6′-trimethoxy-4′-(2,3-epoxy-1-hydroxypropyl)-5-(3-hydroxy-1-propenyl)-biphenyl and 2-hydroxy-3,2′-dimethoxy-4′-(2,3-epoxy-1-hydroxypropyl)-5-(3-hydroxy-1-propenyl)-biphenyl, were isolated from the wood of Eurycoma longifolia and their structures characterized by spectroscopic means.
Author Keywords: Eurycoma longifolia; Simaroubaceae, wood; biphenylneolignan; biphenyl ether; biphenyl.

New antiulcer quassinoids from Eurycoma longifolia
Nouveaux quassinoïdes antiulcéreux à partir d'Eurycoma longifolia
Abstract
A bioassay study of Pasak bumi (Eurycoma longifolia) led to the isolation of four quassinoids, pasakbumin-A (1), -B (2), -C (4), and -D (7). Both pasakbumin-A (= eurycomanone) 1 and pasakbumin-B 2 exhibited potent antiulcer activity. This prompted us to test some modified quassinoids to reveal that ailanthone (8), the main quassinoid of Ailanthus altissima, and its -epoxide (9) have potent activity and less toxicity. Thus, quassinoids which are generally recognised as antitumor compounds were revealed to have antiulcer activity.
Résumé
Une étude de Pasak bumi (Eurycoma longifolia) a conduit à l'isolement de quatre quassinoïdes, pasakbumine-A (1), -B (2), -C (3), et -D (4). Les pasakbumine-A (eurycomanone) 1 et -B, 2, présentent une forte activité antiulcéreuse. Quelques quassinoïdes modifiés ont montré que l'ailanthone (8), le quassinoïde majeur d' Ailanthus altissima, et son époxyde (9) ont une activité puissante et une faible toxicité. Ainsi, des quassinoïdes généralement reconnus comme antitumoraux ont manifesté une activité antiulcéreuse.
Author Keywords: quassinoid; pasakbumins; ailanthone; ailanthone -epoxide; Pasak bumi; Eurycoma longifolia; Ailanthus altissima; Simaroubaceae; antiulcer activity

A quassinoid glycoside from the roots of Eurycoma longifolia
Abstract
A new quassinoid glycoside, eurycomanol-2-O-β- -glycopyranoside, and eurycomanol have been isolated as antimalarial components of Eurycoma longifolia.
Author Keywords: Eurycoma longifolia; Simaroubaceae; eurycomanol-2-O-β- -glucopyranoside; eurycomanol; quassinoid; antimalarial.

Eurycomanone and eurycomanol, quassinoids from the roots of Eurycoma longifolia Abstract
From the roots of Eurycoma longifolia, used as an Indonesian folk medicine, two highly oxygenated quassinoids, named eurycomanone and eurycomanol were isolated. The structures of both new bitter principles were elucidated by NMR, MS, UV and IR.
Author Keywords: Eurycoma longifolia; Simaroubaceae; quassinoids; eurycomanone; eurycomanol.

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