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Ginseng refers to species within Panax, a genus of 11 species of slow-growing perennial plants with fleshy roots, in the family Araliaceae.
They grow in the Northern Hemisphere in eastern Asia (mostly northern China, Korea, and eastern Siberia), typically in cooler climates; Panax vietnamensis, discovered in Vietnam, is the southernmost ginseng found.
This article focuses on the Series Panax ginsengs, which are the adaptogenic herbs, principally Panax ginseng and P. quinquefolius. Ginseng is characterized by the presence of ginsenosides.

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Ginseng Research
Analysis of ginsenosides in Panax ginseng in high pressure microwave-assisted extraction
High pressure microwave assisted extraction (HPMAE) was applied to extract the ginsenosides from Panax ginseng root. The influences of extraction solvent, extraction pressure and extraction time were individually investigated. HPMAE has been compared with other extraction methods, including Soxhlet extraction, ultrasound-assisted extraction and heat reflux extraction. The determination of ginsenosides was performed by HPLC–ESI-MS. The results indicated that the HPMAE not only took a shorter time but also afforded higher extraction yields of ginsenosides, especially ginsenoside Rb1, Rc, Rb2 and Rd. Furthermore, the neutral ginsenosides and malonyl ginsenosides in Panax ginseng root extracts by HPMAE were investigated. The malonyl ginsenoside m-Rb1, m-Rc, m-Rb2and m-Rd degraded in HPMAE at 400 kPa (109–112 °C) in 70% (v/v) ethanol–water and at 600 kPa (112–115 °C) in methanol, and transformed into corresponding neutral ginsenoside Rb1, Rc, Rb2 and Rd. Using water as extraction solution, the neutral ginsenosides degraded under HPMAE at 400 kPa (135–140 °C), and transformed into less polarity rare ginsenosides.
Keywords: Microwave assisted extraction; Panax ginseng; Ginsenoside; HPLC/MS; Degradation

Differentiation of Asian ginseng, American ginseng and Notoginseng by Fourier transform infrared spectroscopy combined with two-dimensional correlation infrared spectroscopy
The herbal materials of Asian ginseng (the root of Panax ginseng), American ginseng (the root of Panax quinquefolius) and Notoginseng (the root of Panax notoginseng) were differentiated by conventional Fourier transform infrared spectroscopy (1D-FTIR) and two-dimensional (2D) correlation FTIR applying a thermal perturbation. Altogether 30 samples were collected and analyzed. Their entire 1D-FTIR spectra in the range of 4000–400 cm−1 and 2D-FTIR spectra in the region of 850–1530 cm−1 were generally similar based on the peaks position and intensities. This indicated the chemical constituents in these species of herbs were not distinctively different. However, variation in peak intensity were observed at about 1640 cm−1, 1416 cm−1, 1372 cm−1 and 1048 cm−1 in the 1D-FTIR spectra among these species for their ease differentiation. Clustering analysis of 1D-FTIR showed that these species located in different clusters. Much difference in their second derivative FTIR pattern among the three species also provided information for easy differentiation. These species of herbs were further identified based on the positions and intensities of relatively strong auto-peaks, positive or negative cross-peaks in their 2D-FTIR spectra. The findings provide a rapid and new operational procedure for the differentiation of these notable herbs. The visual and colorful 2D-FTIR spectra can provide dynamic structural information of chemical components in analyte and demonstrated as a powerful and useful approach for herbs identification.
Keywords: Panax ginseng; Panax quinquefolius; Panax notoginseng; Identification; Fourier transform infrared spectroscopy

Differentiation of the root of Cultivated Ginseng, Mountain Cultivated Ginseng and Mountain Wild Ginseng using FT-IR and two-dimensional correlation IR spectroscopy
Ginseng is one of the most widely used herbal medicines. Based on the grown environments and the cultivate method, three kinds of ginseng, Cultivated Ginseng (CG), Mountain Cultivated Ginseng (MCG) and Mountain Wild Ginseng (MWG) are classified. A novel and scientific-oriented method was developed and established to discriminate and identify three kinds of ginseng using Fourier transform infrared spectroscopy (FT-IR), secondary derivative IR spectra and two-dimensional correlation infrared spectroscopy (2D-IR). The findings indicated that the relative contents of starch in the CG were more than that in MCG and MWG, while the relative contents of calcium oxalate and lipids in MWG were more than that in CG and MCG, and the relative contents of fatty acid in MCG were more than that in CG and MWG. The hierarchical cluster analysis was applied to data analysis of MWG, CG and MWG, which could be classified successfully. The results demonstrated the macroscopic IR fingerprint method, including FT-IR, secondary derivative IR and 2D-IR, can be applied to discriminate different ginsengs rapidly, effectively and non-destructively.
Keywords: Cultivated Ginseng (CG); Mountain Cultivated Ginseng (MCG); Mountain Wild Ginseng (MWG); FT-IR; Discrimination
Abbreviations: CG, Cultivated Ginseng; MCG, Mountain Cultivated Ginseng; MWG, Mountain Wild Ginseng

Effect of processing methods on the concentrations of bioactive components of ginseng (Panax ginseng C.A. Meyer) adventitious roots
Adventitious roots of Korean mountain ginseng (Panax ginseng C.A. Meyer) were processed by using forced air drying methodology at 30, 50 and 70 °C for 1, 3, 5, 10 and 20 h with objective of developing suitable processing/drying technique. Drying of adventitious roots at 50 °C for 10 h was found suitable as desirable moisture content (3.13 g water/dry matter i.e. 10%) could be reached with dried roots. Roots which were dried by such treatment were also possessing higher amount of ginsenosides (1.5 mg g−1 DW triols, 15.9 mg g−1 DW diols and 17.4 mg g−1 DW of total ginsenosides) and phenolics. Adventitious roots were also processed by using far infrared and freeze drying methods and results revealed that forced air drying method is superior to far infrared and freeze drying methods.
Keywords: Adventitious roots; Forced air drying; Far infrared drying; Freeze drying; Ginseng;

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